Like a blue jewel in the
depths of space, the Earth spins on its axis as it orbits round the fireball of
its yellow star. It is indeed a very special planet, an oasis in the cosmos,
teeming with superabundant life. Even if primitive life exists beneath the
ice-cap of Europa or lies hidden under the permafrost of the cold and arid
deserts of Mars, it is only on Earth that highly evolved organisms are to be
found in our Solar System. To discover another world similar to Earth we should
have to travel across the vast abyss of interstellar space to an extra-solar
planet beyond the Empire of the Sun.
Although we only know about
life on our own planet, we can make intelligent hypotheses about the conditions
necessary for life to arise and of what it may be like elsewhere. We shall
assume for the purposes of this web-site that many, if not all forms of life
will be governed by a similar biochemistry to our own. With this in mind it is
proposed to outline the principles upon which life on Earth is based and then to
move on and discuss possible variations that may exist on planets belonging to
other star systems.
Life on Earth
The "Black Smokers"
In 1977, an American deep-sea
research vessel was investigating underwater volcanoes near the Galapagos
Islands. They found that three kilometres beneath the surface of the ocean hot
water was spouting from volcanic vents on the ocean floor. Under high
temperatures and pressures a cocktail of chemicals was liberated that would
normally be lethal to most known forms of life. Here at temperatures far higher than
most enzymes could operate and in a brew of deadly poisons, such as hydrogen
sulphide, a whole new ecosystem was discovered. As time went by other regions
of the ocean floor were found where similar conditions existed. These undersea
volcanoes are called "black smokers"
and their discovery has led to a revolution in the science of
biogenesis. Great concentrations
of ‘bacteria’ were discovered in the vicinity of the volcanic vents. They depend
on chemical reactions taking place around the vent - such organisms are called
CHEMOTROPHIC. In the stygian darkness of the abyssal depths, where sunlight
never penetrates, strange unknown fish and blind white crabs were clustered
around the worms and clams. They depend for their food supply upon the
bacteria and archae that are at the bottom of the food chain. The theory has been
advanced that it was in such
hydrothermal vent environments that life began rather than in the shallow
waters of some ancient shoreline when the world was young.
Recent studies of genetic
sequences of living organisms suggests that the most probable ancestors of
living organisms were in fact sulphur-loving microbes that lived at high
temperatures. It has long been known from the study of organisms living in
hot-springs that there are life forms capable of thriving at much higher
temperatures than had previously been believed possible. They are called
THERMOPHILIC ORGANISMS. Organisms living on the ocean floor near the vents do
not rely on photosynthesis but derive their energy from chemical reactions,
which take place between sulphur compounds. Much information can be from
NOAA.
The Archaea
The Domain Archaea
wasn't recognized as a major domain of life until quite recently. Until the 20th
century, most biologists considered all living things to be classifiable as
either a plant or an animal. By the 1970s, a system of Five Kingdoms had come to
be accepted as the model by which all living things could be classified. At a
more fundamental level, a distinction was made
between the prokaryotic
bacteria and the
four
eukaryotic kingdoms
The distinction recognizes the common traits that eukaryotic organisms
share, such as nuclei, cytoskeletons, and internal membranes.
In the 1970s Dr.
Carl Woese and his colleagues at the University of Illinois were studying
relationships among the prokaryotes using DNA sequences, and found that there
were two distinctly different groups. Those "bacteria" that lived at high
temperatures or produced methane clustered together as a group well away from
the usual bacteria and the eukaryotes. Because of this vast difference in
genetic makeup, Woese proposed that life be divided into three domains:
Eukaryota, Eubacteria, and Archaebacteria. He decided that the term
Archaebacteria was a misnomer, and shortened it to Archaea.
Most Archaea don't
look that different from bacteria under the microscope, and that the extreme
conditions under which many species live has made them difficult to culture, so
their unique place among living organisms long went unrecognized. However,
biochemically and genetically, they are as different from bacteria as human
beings are!
Illustration Family Tree of Life on Earth.

Many thanks are due to Dr
Bharat Patel for permission to reproduce the above diagram Website
http://trishul.sci.gu.edu.au/~bharat/courses/ss13bmm/archaea...
Dr Bharat Patel, Associate Professor Microbial Technology and Director Clinical
Microbiology Programme, Faculty of Science and Technology. Griffith University
(Nathan Campus), Brisbane, Australia 4111
Work was also carried out on the
sequencing of a certain type of RNA molecule (16S RNA molecules) that supported
the classification of life into the three domains. The new taxonomy
includes a new form of classification involving DOMAINS
Eukarya Domain – four kingdoms
- Protista Fungi Plants Animals
Prokaryota
Domain –one kingdom Bacteria
Archaea Domain- probably three
kingdoms Many of them are extremophiles : that is to say they live and
thrive under conditions that are very extreme
Thermophiles can live at 85-115 degrees Celsius in superheated water under
pressure.
Cryophiles can live at minus 5 degrees in freezing water
Halophiles can live in water containing very high concentrations
of salts
Acidophiles can tolerate very high acids (low pH)
Alkalinophiles can tolerate very high alkaline conditions (low
pH)
Most archae and some bacteria derive their energy from chemical
reactions in environments that would be very highly toxic to oxygen 'breathing'
organisms. Substances such as cyanides and hydrogen sulphide are common in
such environments. They are said to be Anaerobic. Free oxygen is
a deadly poison to such organisms. Organisms that depend on Oxygen are said
to be Aerobic.
It is now believed by many scientists that the archaea are the
common ancestors to all forms of life on the planet and originated at high
temperatures and pressures in volcanic vents.
If this is how life started on
our own planet, it is possible that similar processes took place on Mars and
Europa. Deep beneath the permafrost of the cold Martian surface there may yet
be places where chemotrophic organisms still exists. The exploration
of the red planet has only
just started but as detailed surveys are carried out in the next few decades
Mars may yet yield up fascinating secrets to future explorers. Much interest
too is focussed on Europa and plans are already being made to investigate the
possible existence of present day life in an ocean beneath the ice-cap.
In searching for life on Mars or
Europa there are two precautions that must be vigorously observed. Both concern
cross-contamination. We must be certain that any forms of life found on either
of those two worlds are not contaminated by something that has come on a
spacecraft from Earth. Even more important any samples brought back from other
planets to Earth must not be allowed to contaminate our environment with an
alien life form.
“The Oxygen Revolution”
Near the southwest coast of
Australia a biologist by the name of Linda Moore is investigating a group of
primitive photosynthetic organisms known as CYANOBACTERIA (formerly called
blue-green algae). They grow on rocks and the rock/bacterial formations are called
STROMATOLITES.
Working in another
part of Australia, J. William Schopf discovered some 3.46 billion year old fossils in a
rock called the Apex rock. He claims that they are very similar to the present
day organisms studied by Linda Moore. He believes that in those far off times
stromatolites were clustered round the coasts of volcanic islands. The Earth
was a very different place then to what it now is. A pale
yellow Sun noticeably dimmer than it is at present raced rather quickly across
the heavens and the day lasted less than 18 hours. At night a huge brilliant
Moon far closer to the Earth than it is now hung in a sky filled with a totally
different pattern of star constellations. There was no oxygen in the atmosphere
but the blue-green organisms that covered the rocks were just starting to grow
and were about to alter all that. Very slowly but inexorably the cyanobacteria
brought about a momentous change in the planet’s environment. Sometimes it is
referred to as THE OXYGEN REVOLUTION.
The cyanobacteria had
found a way of utilising the light of the Sun as a source of energy.
Photosynthesis had begun. Molecular oxygen was produced as a bye-product. For
any ANAEROBIC organisms the atmosphere and the sea-water became contaminated
with a very toxic gas. Most of the organisms died except for the cyanobacteria
and a few others that had found ways of defending themselves against the toxic
effects of oxygen. These oxygen-resistant bacteria (AEROBIC organisms) adapted
and actually began to use the ‘poison’ to their enormous advantage. They were
able to extract about sixteen times as much energy from the ‘food’ as the
anaerobes. It appears to have taken a very long time for oxygen to accumulate
to high levels in the atmosphere so it was a very slow revolution. The
oxygen initially formed reacted with reducing substances in the environment, the
most important of which was iron in its divalent ferrous (Fe++)
form. Sea-water used to contain a lot of ferrous iron in solution. Evidence
for its reaction with oxygen is seen in the banded rocks of alternating green
ferrous and yellow brown ferric (Fe++) iron found in strata laid down
during the early years of the oxygen revolution.
Stromatolite Rock Formations

In the hyper-saline water of Hamelin Pool
at the base of Shark Bay in Western Australia the rocks aren’t quite what
they appear to be. They are living things, Stromatolites, which are a very
ancient form of life on the planet. Stromatolites are the result of
primitive life forms that first existed on Earth 3.5 billion years ago. The
dome shaped structures reach up to 60cm in height and are formed by
cyanobacteria.
Hamelin Pool is the location of the best example in the world of living
marine stromatolites. The water of Hamelin Bay is twice as saline as usual
sea water because of a bar across the Bay's entrance and rapid evaporation
from the shallow water. Most living animals, which feed on the bacteria and
algae of which stromatolites are composed, cannot tolerate such saline
conditions. As a result stromatolites can grow here successfully,
undisturbed. Most stromatolites are extremely slow growing. Those in Hamelin
Pool grow at a maximum of .3mm a year, so those which are up to a metre high
are hundreds of years old.
Acknowledgement of Picture ‘Discover West Holidays – Western Australia
Holiday Planning’
For at least three-quarters of
the Earth's history stromatolites were the main reef building organisms However
their most important role in Earth’s history has been contributing oxygen
to the earth's atmosphere. The
organisms which construct stromatolites are photosynthetic. They take carbon
dioxide and water to produce carbohydrates, and in doing this they liberate
oxygen. When stromatolites first appeared on earth about 3.5 billion years ago
there was little or no oxygen in the atmosphere. It was through the
oxygen-generating activity of stromatolites that animal life on earth was able
to develop.
There is evidence that
Stromatolite fossils were found in very early rocks. Western Australia perhaps has the best stromatolite fossils,
giving a record through the eons of time. The present day stromatolites at
Hamelin Pool gives an indication of what the earth may have looked like 3.5
billion years ago when stromatolites were widespread. Because of their range and
numbers it is a place of great interest to botanists and geologists alike.
It's a humbling thought that the great change in life, which is believed to have
started with oxygen hating anaerobic archaea and bacteria was probably brought
about by the stromatolites
A wide range of stromatolite fossils can be seen in the Western
Australian Museum at Perth.
The Atoms of Life
Twenty-four chemical elements are
known to play a role in life processes on our planet. Six of them predominate
and help to build the very large molecules, which make up living matter. They
are CARBON, HYDROGEN, OXYGEN, NITROGEN, SULPHUR and PHOSPHORUS. Five other
elements occur in significant quantities. They are the metals SODIUM, POTASSIUM,
MAGNESIUM and CALCIUM largely in the form of their cations and the non-metal CHLORINE in the form of the chloride anion.
Although only present
in tiny amounts, trace elements are also essential for most living organisms.
For example, IRON is needed for blood haemoglobin and a number of important
enzymes. Other trace elements are VANADIUM, CHROMIUM, COBALT, NICKEL, COPPER,
ZINC, MOLYBDENUM, BORON, FLUORINE, SILICON, SELENIUM and IODINE
The Molecules of Life
There is a vast repertoire of
carbon compounds that play a role in living processes. Despite their vast
diversity, all the living organisms on Earth use similar types of molecules.
They use small molecules such as sugars, fatty acids, amino acids and nitrogen
bases. These small molecules join together to form very large assemblages of
atoms called polymers or
MACROMOLECULES (very large molecules). All forms of life on Earth depend upon
a few basic types of macromolecules of which the most important are the nucleic
acids and the proteins.
The Genetic Code.
The Nucleic Acids
The nucleic acids carry the
genetic code. There are two main types, RNA and DNA. Many scientists
consider that life began using RNA as the primary carrier of the code. A
few viruses called retroviruses use RNA as the genetic material but DNA carries
the genetic messages for all cellular life forms.
DNA is an extremely stable molecule and it is used to pass on the
genetic messages from one generation to the next.
DNA also plays its part in the moment-to-moment work of all
living cells. To ensure that the correct proteins are produced, molecules of
messenger-RNA are synthesized in the cell nucleus on the surface of the DNA.
DNA
is always double stranded - hence the name of the famous book by Watson 'The
Double Helix'.

Because DNA is an extremely
stable molecule, the same messages can be passed from one generation to the
next. 'Mistakes' (mutations) are rare but very occasionally occur a base change or a
deletion can occur which leads to a mutation.
DNA is used to pass the genetic
message on to future generations of living cells. Before a cell can divide to
produce a daughter cell, the DNA molecules in the nucleus of the cell have to
produce a full complement of daughter molecules. When a DNA molecule reproduces
a copy of itself, the double helix is progressively zipped open and the
nucleotide sub-units are connected in the same order as the mother molecule
using as the catalyst a system of enzymes called collectively DNA polymerase.
Besides its role in passing on the genetic message from one
generation to the next, DNA also plays its part in the moment-to-moment work of all
living cells. To ensure that the correct proteins are produced, molecules of
messenger-RNA are synthesized in the cell nucleus on the surface of the DNA.
Messenger RNA
molecules are single stranded. In both forms of nucleic the main strand is composed
of a helix of a repeating sugar unit (Ribose or deoxyribose) joined by a
phosphate group. Each sugar unit is connected to a nitrogen base.
There are four mononucleotide nitrogen bases and it is these bases that carry
the genetic code.
| Nitrogenous Base |
Mononucleotide |
Full Abbreviation |
Short
Abbreviation |
Found in DNA |
Found in RNA |
| Adenine |
Adenosine monophosphate |
AMP |
A |
Found in both |
Found in both |
| Cytosine |
Cytosine monophosphate |
CMP |
C |
Found in both |
Found in both |
| Guanine |
Guanine monophosphate |
GMP |
G |
Found in both |
Found in both |
| Thymine |
Thymine monophosphate |
TMP |
T |
Found in DNA only |
|
| Uracil |
Uracil monophosphate |
UMP |
U |
|
Found in RNA only |
DNA is an extremely stable molecule and it is used to pass on the
genetic messages from one generation to the next.
DNA also plays its part in the moment-to-moment work of all
living cells. To ensure that the correct proteins are produced, molecules of
messenger-RNA are synthesized in the cell nucleus on the surface of the DNA. The messenger-RNA then carries the code out of the cell nucleus to a RIBOSOME.
The word ribosome is the name given to a cellular ‘factory’ where proteins are
made. At the ribosomes small amino acid molecules are fused together to an
exactly genetically determined recipe to produce specific proteins. A
randomly produced protein would be of no biological use whatsoever.
Most energy reactions
in living organisms use a biochemical system involving Adenosine triphosphate
and adenosine diphosphate (abbreviated to the ATP/ADP system). It should also be noticed that it is one of the important sub units in
DNA and RNA.
Their are 4 different LETTERS in the DNA code. Three
letters are required to code for a protein. Thus their are 64 different
DNA words. The DNA molecules do not code for proteins DIRECTLY but
pass on their messages in the nucleus of the cell to messenger RNA molecules.
This is done by a process analogous to the production of a positive picture from
a negative in ordinary photography. It is this positive message that is
transported across the membrane of the nucleus to the protein factories of
RIBOSOMES. Here by a series of chemical reactions the messenger RNA passes
on the genetic code to another type of RNA called ribosomal RNA. This is a
long protein molecule is formed from amino acids in the correct genetically
determined sequence. The protein takes up the correct shape required
and is then ready to carry out its function with in the organism.
The Diagram lists the 64 code words used by messenger
RNA and the names of the amino acids for which each word codes. The
technical term for the code word is CODON.
Table : RNA codon table
This table shows the 64 codons and the amino acid
each codon codes for.
| |
2nd base |
| U |
C |
A |
G |
1st
base |
U |
UUU (Phe/F)Phenylalanine
UUC (Phe/F)Phenylalanine
UUA (Leu/L) Leucine
UUG (Leu/L)Leucine
|
UCU (Ser/S)Serine
UCC (Ser/S)Serine
UCA (Ser/S)Serine
UCG (Ser/S)Serine
|
UAU (Tyr/Y)Tyrosine
UAC (Tyr/Y)Tyrosine
UAA Ochre (Stop)
UAG Amber (Stop)
|
UGU (Cys/C)Cysteine
UGC (Cys/C)Cysteine
UGA Opal (Stop)
UGG (Trp/W)Tryptophan
|
| C |
CUU (Leu/L)Leucine
CUC (Leu/L)Leucine
CUA (Leu/L)Leucine
CUG (Leu/L)Leucine
|
CCU (Pro/P)Proline
CCC (Pro/P)Proline
CCA (Pro/P)Proline
CCG (Pro/P)Proline
|
CAU (His/H)Histidine
CAC (His/H)Histidine
CAA (Gln/Q)Glutamine
CAG (Gln/Q)Glutamine
|
CGU (Arg/R)Arginine
CGC (Arg/R)Arginine
CGA (Arg/R)Arginine
CGG (Arg/R)Arginine
|
| A |
AUU (Ile/I)Isoleucine
AUC (Ile/I)Isoleucine
AUA (Ile/I)Isoleucine
AUG (Met/M)Methionine Start
|
ACU (Thr/T)Threonine
ACC (Thr/T)Threonine
ACA (Thr/T)Threonine
ACG (Thr/T)Threonine
|
AAU (Asn/N)Asparagine
AAC (Asn/N)Asparagine
AAA (Lys/K)Lysine
AAG (Lys/K)Lysine
|
AGU (Ser/S)Serine
AGC (Ser/S)Serine
AGA (Arg/R)Arginine
AGG (Arg/R)Arginine
|
| G |
GUU (Val/V)Valine
GUC (Val/V)Valine
GUA (Val/V)Valine
GUG (Val/V)Valine
|
GCU (Ala/A)Alanine
GCC (Ala/A)Alanine
GCA (Ala/A)Alanine
GCG (Ala/A)Alanine
|
GAU (Asp/D)Aspartic acid
GAC (Asp/D)Aspartic acid
GAA (Glu/E)Glutamic acid
GAG (Glu/E)Glutamic acid
|
GGU (Gly/G)Glycine
GGC (Gly/G)Glycine
GGA (Gly/G)Glycine
GGG (Gly/G)Glycine
|
The second table shows the amino acids and the codons which code for each
amino acid in the table
Table: Reverse codon table
This table shows the 20 standard amino acids used in
proteins, and the codons that code for each amino acid.
| Alanine |
GCU, GCC, GCA, GCG |
Leucine |
UUA,UUG,CUU,CUC,CUA,CUG |
| Arginine |
CGU, CGC, CGA, CGG, AGA, AGG |
Lysine |
AAA, AAG |
| Aspartic acid |
AAU, AAC |
Methionione |
AUG |
| Asparagine |
GAU, GAC |
Phenylalanine |
UUU, UUC |
| Cystein |
UGU, UGC |
Proline |
CCU, CCC, CCA, CCG |
| Glutamic acid |
CAA, CAG |
Serine |
UCU, UCC, UCA, UCG, AGU, AGC |
| Glutamine |
GAA, GAG |
Threonine |
ACU, ACC, ACA, ACG |
| Glycine |
GGU, GGC,GGA,GGG |
Trptophane |
UGG |
| Histidine |
CAU, CAC |
Tyrosine |
UAU, UAC |
| Isoleucine |
AUU, AUC, AUA |
Valine |
GUU, GUC, GUA, GUG |
| Start |
AUG |
Stop |
UAG, UGA, UAA |
Many codons are redundant, meaning that two or more codons
can code for the same amino acid. e.g., both GAA and GAG code for the amino acid GLUTAMINE
This is analogous to the letters C and K. C is a redundant
letter and could always be replaced by K. Thus there is no reason why the
word CAT should not be spelt KAT Degenerate codons may differ in their third
positions.
There a few variations that do
exist - a few 'dialects' in a few organisms. However,
despite
the variations that do exist, the genetic codes used by all known forms of life
on Earth are very similar. Since there are many possible genetic codes that are
thought to have similar utility to the one used by Earth life, the theory of
evolution
suggests that the genetic code was established very early in the history of
life.
The RNA Hypothesis
It is believed that before the
coming of cellular life there was a gradual molecular evolution. The build up
of complex chemicals was most likely catalysed by clays containing iron and
smaller amounts of other metals. A strongly held opinion, known as the RNA
Hypothesis suggests that simple molecules containing carbon, hydrogen, oxygen,
nitrogen and phosphorus reacted at the catalytic surfaces of minerals, possibly
clays, to form a group of large complex molecules called RIBONUCLEIC ACIDS
(RNA). For this purpose energy was required and this was obtained from chemical
reactions which took place in the environment. One of the most important energy
donating chemicals even at this early stage of evolution was probably ADENOSINE
TRIPHOSPHATE or ATP. According to the theory these early forms of RNA acquired
the capacity to catalyse the production of molecules identical to themselves
without the need of inorganic substances such as the clays. The first stage of
biochemical life began by the production of ‘daughter molecules’ identical to
the ‘mother molecules’. Occasionally ‘mistakes’ were made in the copying
mechanism giving rise to ‘mutant molecules’. Eventually there were a large
number of different types of RNA competing with one another in the environment.
Chemical evolution had begun. The RNA molecules were both the first biochemical
catalysts (enzymes) and the first carriers of genetic messages.
RNA molecules consist of long
strands of alternating units of a sugar called RIBOSE and of PHOSPHATE IONS.
These form the spine of the RNA molecule. Each of the sugar sub-units carries a
nitrogen base. Only four bases are found in naturally occurring RNA. For
simplicity these bases are denoted by letters A, G, C and U where A=ADENINE,
G=GUANINE, C=CYTOSINE and U=URACIL. The alternating phosphate and ribose
sub-units form the spine of a rod-like spiral molecule, which carries an
extremely long sequence of the nitrogen bases. RNA molecules only differ from
one another in the length and the sequence
of their nitrogen bases.
Further stages in this pre-biotic
chemical evolution eventually resulted in the synthesis of proteins and DNA.
The proteins
were more efficient catalysts than RNA and took over the enzyme functions.
Another change that occurred was that DNA took over the genetic role. DNA
differs from RNA in that it uses DEOXYRIBOSE instead of ribose And THYMINE
(T) instead of uracil as shown in the above table.
An even more recent theory
suggests that the first self-replicating molecules did not belong to the RNA
group but to a group of related chemicals called PEPTIDE NUCLEIC ACIDS or PNA.
These are a kind of hybrid group of molecules in between RNA and proteins in
which the sugar ribose is replaced by peptide links attached to the A, G, C and
U bases. Unlike RNA these compounds are stable at 100oC. It is
likely that the early Earth was very hot. Also black smokers are surrounded by
extremely hot water..
It is supposed that at some stage
the RNA, DNA and proteins were encapsulated in protected membranes and simple
cellular life began. Early theories about the origins of life suggested that it
began in shallow sunlit pools. This theory has however been very strongly
challenged, since without an ozone layer early life forms would have been
constantly destroyed by the ultra-violet radiation from the Sun.
Proteins
Proteins are composed of amino
acids linked together to form long chains of atoms.
They play a vital role in the
functioning of biological systems from the simplest viruses and bacteria to the
most complex plants and animals.
Two amino acids can be joined together by what chemists call a
peptide link to form a dipeptide molecule and a water
molecule.
Several peptides can be
united to give a polypeptide.
A
water molecule is split out when each peptide link is formed.
Proteins are formed by the union of a large number of amino
acids. As previously mentioned to
be of ‘biological
use’, proteins are ‘manufactured ‘ according to exact genetic recipes
carried by the messenger-RNA molecules.
Proteins are composed of amino
acids linked together to form long chains of atoms.
They play a vital role in the
functioning of biological systems from the simplest viruses and bacteria to the
most complex plants and animals.
Amino acids possess an amino
group, a carboxylic acid group, a hydrogen atom and a fourth group, which varies
from one amino acid to another. They are all attached to the same carbon atom.
Where they differ from one another is in the nature of the group of atoms, which
occupy the fourth valency position on the carbon atom.
The possible number of amino acids must run into millions but
only a few of them are of biological
interest. Only twenty of them are
usually found in proteins.
They are listed below:-
Alanine
Leucine Isoleucine
Valine Proline Phenylalanine
Tryptophan
Methionine Glycin
Serine
Threonine Tyrosine
Cysteine Glutamine
Arginine
Aspartic acid
Glutamic acid
Lysine
Histidine
Asparagine
A few more do occur rarely in proteins but these will not be
discussed here.
The number of proteins produced by the differing arrangements of
these amino acids is enormous.
The general
structure of all amino acids found in proteins can be represented by the formula
H
R -C -COOH
where R denotes the relevant group of atoms
NH2
One of the simplest amino acids
is ALANINE which has the formula
H
H3 C - C - COOH R
is a -CH3 group. It is called a methyl group.
NH2
When a
carbon atom is surrounded by four different atoms or groups of
atoms it can exist is two different arrangements in space.
The two types are called optical isomers of one another
or two handed (chiral) varieties. All the amino acids occurring
in proteins with the sole exception of glycine can exist in the
two forms.
The two
forms of the amino acid alanine are shown below
.
However only one form is found in proteins See
web-page on van't Hoff for diagram of two forms of alanine
Although, only
L- amino acids such as L-alanine are used to build up into proteins on
our planet, there seems to be no apparent reason why one form should be
preferred over the other. There
might well be biochemical systems on other planets where only the
D-forms of amino acids are used in the synthesis of proteins.
The fate of a hypothetical Earthman or Earthwoman, after
travelling through a wormhole to such a mirror world, would indeed be a
sad one. However good the food
seemed to be they would soon die of starvation since the mirror image
'food' would be of no use whatsoever!
Also alien proteins may well have a different mix of amino acids to
those on Earth
Carbon is the fourth most
abundant atom in the cosmos and is a substance of enormous versatility. The
process of the building up of molecules containing long chains and rings of
carbon atoms together with hydrogen, oxygen and nitrogen starts early, even at
the freezing temperatures of the interstellar dust clouds. Some prebiotic
molecules such as carbon monoxide, hydrogen cyanide, ethyl alcohol, amines and
amino acids have been detected in the Orion Nebula and similar nebulae where planetary
systems appear to be forming.
Ever since the Renaissance in
Europe many members of the scientific community have suspected that apart from
our Sun, some other stars may be accompanied by planets. As early as 1698
Christiaan Huygens attested his belief in the existence of other worlds
inhabited by plants and animals in his book 'The Celestial Worlds'.
In 1600 ' Giordanno Bruno was burnt at the stake as a heretic.
One of his heresies was to postulate that the stars were suns and some of them
were accompanied by planets on which there were people living.
Already there is evidence that
nearby stars are accompanied by large planets as massive as or more massive than
Jupiter. These large planets have been detected by the wobble they produce in
the star during the course of their orbit. It requires the use of
extraordinarily sensitive measurements by what are called ASTROMETRIC
techniques. They are called
Extra-solar Planets and are dealt with in another section of this web site.
It is believed that there are many smaller terrestrial type planets and some of
these may be abodes of life. The Darwin project and other future advances
within the next decade are planned and it is possible that spectroscopic
evidence of ozone, carbon dioxide, methane and water may be found on some of
these other worlds.
In considering the
possibility of life on planets of other star systems it is necessary to consider
both the planet and its star. Mathematical studies on planetary evolution and
the habitable zones around stars suggest that advanced life may be restricted to
planets similar to the Earth orbiting stars similar to the Sun.
The Star
It is generally considered
that life-sustaining stars will lie in a range between 80% and 120% of a solar
mass. It has been suggested that planets orbiting very close to small
red dwarf stars could play host to life (see New Scientist 27 January 2001 pages
28-31).
However there would seem to
be a number of limitations.
1)
If the star is variable and subject to violent flares this may make
evolution very difficult. Recently compiled evidence suggests that some stars
of a similar size and composition to our Sun are subject to erratic and violent
flare activity. This may cut down considerably the number of suitable planets
where life could comfortably evolve.
2)
If the stellar system is very deficient in
higher elements large terrestrial planets may be unlikely to form (by higher
elements we mean elements above helium in
the periodic table such as oxygen, carbon,
nitrogen etc which astronomers persist in calling ‘metals’).
3)
If the stellar system is too
near the galactic centre conditions may be too violent and variable for life to
develop.
The Planet
1) any planet suitable for
the evolution of advanced life forms would have to have a mass high
enough to retain an atmosphere. This depends upon the gravitational force at
the surface.
2) It would need to have an
adequate water supply and be within the right temperature range. It is widely
and almost universally believed that biochemical life requires water in the
liquid phase. The only other candidate is liquid ammonia NH3. This
will not be discussed here and for a number of reasons it is most improbable
that worlds exist where there are large amounts of ammonia and very little
water.
3) a planet must orbit its
Sun in a relatively narrow 'continuously habitable life zone'. Had the Earth
been only a few percent closer to the Sun it may have become a furnace like
Venus early in its history. If it had been a few percent further out like Mars,
it may have become frozen in a permanent ice age.
Thus life may be restricted to fairly large sized
terrestrial planets orbiting stable stars in ‘Goldilocks Orbits’. Although
this cuts down the number of places where life may evolve there are still a very
large number of possible star systems where life as we know it may exist. Also there
may be a number of planets such as Europa where large quantities of liquid water
may be present but where the energy to keep the water in the liquid phase is
derived from tidal or other forces.
4) There is another problem that may arise in a
planet where the angle of inclination of the axis to the ecliptic plane is
rapidly undergoing wild variations. Such a situation would cause devastating
changes in the weather conditions and may make it more difficult for life (or
at any rate highly evolved life) to develop. In this connection the possession
of a large moon may be of great help in maintaining fairly stable conditions.
If a terrestrial planet in a suitable orbit (‘Goldilocks orbit”) also needs a
large moon then this would cut down considerably the number of planets where
advanced life would be likely to develop.
It seems likely that simple bacterial-type life may
be relatively common in other ‘solar’ systems but highly evolved life such as
animals and plants may be less common. Nevertheless one day perhaps we
shall have some sort of contact with other intelligent beings who share with us
the stars. It is interesting to speculate what form the chemistry of life would
be likely to take on other planets
Alien Proteins
If a similar situation exists
on another planet like our own we may expect a variation on the theme. For
example, there could be a different repertoire of amino acids making up
the proteins.
Mirror Image Molecules
One of the mysteries of
molecular biology is that there is a bias in the shape of the molecules that
make up living matter. In the second half of the
nineteenth century Louis Pasteur and Johannes Siliceous, discovered that lactic
acid, a simple molecule that is found in living organisms, existed in two
optically active forms. It soon became apparent to them and other workers that
most other compounds that were involved in biochemical processes were similar to
the lactic acids. In most respects, the substances were chemically similar. It
was however found that in general only one of them was biologically active. It
took the scientific world many years to discover the true reasons for the
phenomenon, which is called optical isomerism or chirality. In 1875, two young
chemists, van't Hoff and Le Bel independently offered a satisfactory explanation
for the existence of the pairs of optical isomers.
They realised that in order
to fully show the way in which carbon atoms bond to other atoms it is necessary
to draw a diagram showing the orientation of the atoms in three dimensional
space.
They discovered the simple
fact that if a carbon atom is connected by four single covalent bonds to four
different atoms or groups of atoms A, B, C, and D then two different
arrangements in space are possible. This results in the existence of two
forms of the molecule which are called optical isomers, which are mirror images of one another.
In particular van't Hoff
postulated that the four valencies of a carbon atom are directed towards the
corners of a tetrahedron with the carbon atom at its centre. Geometrical
considerations demand that compounds in which a central carbon atom is bonded to
four groups, all of which are different to each other, must exist in two forms.
These are known as the D-and L-forms or right and left handed forms. Such
compounds are called CHIRAL compounds from the Greek word meaning hand. The
molecules of the two chiral forms are mirror images of one another
and the existence of chiral molecules is of great importance in biochemistry.
With the exception of
glycine all the amino acids found in proteins can exist in two optically active
isomeric forms. They are called the D- and the L- forms.
Many scientists now believe
that life on Earth may have evolved from pre-biotic molecules originally formed
in the gas clouds and incorporate into comets and meteorites. The presence of
amino acids has now been found in the Murchison meteorite. A sample of the amino
acid alanine from the meteorite showed a higher 13C/14C
ratio than is normally found on Earth thus indicating its extra-terrestrial
origin. This proves that amino acids can originate outside the Earth. Although
both isomers are present, the 'left-handed' variety predominated just as it does
in earthly organisms.
Recent work on the Orion
Nebula has detected the presence of circularly polarised ultra violet
radiation. In some regions of the gas cloud it is polarised clockwise and in
others anti-clockwise.
Chemical experiments have
shown that the decomposition of a 50/50 mixture of an optically active substance
by circularly polarised ultraviolet light is affected by the direction of the
polarisation. The rate of decomposition of the two forms vary, according to
the direction of the polarisation. This would suggest that in some regions the
concentration of the L-form would predominate whilst in other regions the D-form
would predominate. Although, only L- amino acids such as L-alanine are used to
build up into proteins on our planet, there seems to be no apparent reason why
one form should be preferred over the other. There might well be biochemical
systems on other planets where only the D-forms of amino acids are used in
the synthesis of proteins. The fate of a hypothetical Earthman or
Earthwoman, after travelling through a wormhole to such a mirror world, would
indeed be a sad one. However good the food seemed to be they would soon die of
starvation since the mirror image 'food' would be of no use whatsoever!
Energy Sources
Assuming the theories of
planetary formation to be more or less correct it would seem that all
terrestrial planets would have volcanic activity. Planets with seas or oceans
would be likely to have underwater volcanoes. It would seem highly probable
that chemotrophic organisms would form colonies around volcanic vents just as
they do on Earth.
The most obvious source of
energy is from starlight. At some stage in the development of life on Earth,
organisms similar to blue green algae developed a way of trapping and utilising
sunlight. On Earth, photosynthesis has developed using a complex enzyme system
that includes a group of compounds called chlorophylls to trap the solar
energy. It seems reasonable to assume that similar systems will have evolved on
other planets. It could well be that the choice of light-trapping catalysts may
be different to chlorophyll. It could be that such a compound may not be green
in colour. There may indeed be planets where the predominant colour of the
plants is blue, yellow, red or orange depending on the colour of the pigment
that plays the main role in the photosynthetic processes.
Another point with regard to
biochemistry on Earth is that most energy transfer changes in biochemical
systems rely on the use of a system in involving the donation of energy from a
molecule of adenosine triphosphate (ATP) which is converted to adenosine
diphosphate (ADP) when it parts with its energy.. It would be interesting to know if other life forms used a
different energy transfer system. In economic analogy would be that
different nations use different currencies - the American Dollar, the Euro, The
Pound sterling.
Alien Genetic Codes
All organisms found on
Earth appear to use the same genetic code..
One of the most intriguing questions is whether or not organisms, which have
evolved on other planets, use the same code, a similar code or something
completely different.
Genetic processes are likely
to be similar in principle to ours. There must be large and stable molecules
capable of holding a huge biochemical library. DNA on Earth is a remarkably
stable macromolecule capable of holding an enormous amount of information.
Because of its stability it is able to hold and pass on its message to the next
generation.
Nevertheless, because it can
occasionally become slightly changed mutations can occur. By natural selection
many mutations will be less successful than their the parent organism or, in
sexual reproduction, the parent organisms but a few will be more
successful so life will not only change but become more and more complicated and
versatile as time goes by. It is possible that there are a number of possible
macromolecules similar to RNA and DNA. They may well have different sub-units
and different sugars. It would be interesting to conjecture on the nature of
the messages encapsulated in the genetic molecules of an alien life form. By a
process of natural-selection, a similar type of coding to our own may well
develop elsewhere, although different sub-units may be used in the actual
DNA-like molecules. If panspermia turns out to be true after all then the
genetic code could even be similar on other inhabited planets.
Panspermia
Following the discovery of
organic molecules in space, particularly ones such as formaldehyde and the amino
acid glycine, the old theory of
Panspermia has been revived. At first sight, it seems an extremely
improbable set of ideas. It was first put forward in a coherent form by the
Swedish chemist Svandte Arrhenius. He postulated that primitive life forms were
present in interstellar space and were carried on comets and meteorites. When
these bodies collided with a planet whose environment was suitable they seeded
it with life which then went on to evolve and produce the higher organisms. If
such a theory were correct, he argued organisms would have to be able to survive
great cold. To support his ideas Arrhenius quoted in his book 'Worlds in the
Making', published in 1908, the results of experiments carried out with bacteria
at the Jenner Institute in London. Bacterial spores were subjected to a
temperature of -252 degrees Celsius using liquid hydrogen for 20 hours. They
still maintained the power to germinate.
Evidence as to the ability of
bacteria to survive extremely harsh environments was discovered after the Moon
landing by one of the early robot space vehicles. In April 1967 Surveyor 3
landed on the Moon. Over two years later in November 1969, members of the Apollo
12 crew retrieved it. On return to Earth the TV camera was examined in
quarantine and found to contain living bacteria of the species Streptococcus
mitis. The bacteria seemed to have survived two years of
exposure to the harsh lunar conditions at almost zero pressure and at
temperatures which varied between plus 100 and minus 150 degrees Celsius.
In the 1960s by Hoyle and
Wickramasinghe again began to support the 'heretical idea' of 'Panspermia'. They argued that bacteria and viruses could probably survive
the cold of interstellar space in the vast molecular gas and dust clouds that
gave rise to the birth of stars. Opponents of the theory argued that, even if
bacteria survived in interplanetary space near a star, they would burn up on
entering the atmosphere of a suitable planet. However, experiments showed that
bacterial spores could survive temperatures of 700 degrees Celsius. Very small
particles the size of bacterial cells would only be heated to temperatures of
around 500 degrees Celsius on entry into the Earth's atmosphere. Also this
temperature would only be maintained for a very short time. Hoyle and Wickramasinghe went even further in their book 'Our place in the Cosmos' and
suggested that bacteria and viruses are still reaching the Earth from outer
space.
Whether panspermia is true or not, it would
seem that organic molecules, such as amino acids, do occur in space and have
reached the Earth on comets and meteorite. They must still be doing so to a
much lesser extent.
The Search for Civilisation
There may be many
planets on which primitive life exists. On the other hand, to provide a stable
habitat for highly advanced forms of life more stringent requirements may be
necessary. Planets on which advanced technological civilisations similar to
ours have formed might be relatively rare.
Whether it may ever be
possible to visit planets orbiting other stars depends upon one important
consideration. That is whether the laws of physics permit us to do so. If the
speed of light is a totally limiting factor and there is no other way of
overcoming the gigantic distances between the stars then, however brilliant our
technology becomes, we will never be able to visit civilisations existing in
other star systems.
On the other hand if the
universe is stranger than we have hitherto imagined, then future generations may
indeed discover a means of travelling in some way, as yet unenvisaged at 'warp
speed' through wormholes in space-time' to planets orbiting other suns.
Even if interstellar travel
proves impossible, we may be able to communicate with relatively nearby
civilisations by radio and even television. Judging by the number of sun-like
stars there is a strong possibility that there are planets with advanced
civilisations near enough for this to be possible. If this ever comes about it
will certainly answer many of our questions about the nature of life. It will
indeed alter our whole philosophy even more than the revolution of Copernicus if
we learn for certain that we are not alone in the Universe.
Numerous attempts have been
and are still being made to try and detect signals from other civilisations
through projects such as SETI (the Search for Extra-terrestrial Intelligence).
This is discussed in the section of this web-site dealing with
SETI.
Home Page
van't Hoff
Arrhenius